ALK-3 / BMPR1A / CD292 Molecule
BMPR-IA / ALK-3 Molecule Synonym Name
BMPR-IA / ALK-3 Protein Products
|Cat No||Species||Product Description|
|AL3-H5228||Human||Human BMPR-IA / ALK-3 Protein|
|AL3-H5259||Human||Human BMPR-IA / ALK-3 Protein, Fc Tag|
BMPR-IA / ALK-3 Molecule Background
The bone morphogenetic protein receptor, type IA is also known as BMPR1A or ALK3 is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 (cluster of differentiation 290). The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. Alk3-mediated BMP signaling in AV endocardial/mesenchymal cells plays a central role during cushion morphogenesis.
- (1) Mishina Y, Starbuck MW , et al.,2004, J. Biol. Chem. 279 (26): 27560–6.
- (2) Song L, F?ssler R, et al., 2007, Dev Biol. 301(1):276-86.