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IL-13 Molecule Synonym Name  


IL-13 Molecule Synonym Name

IL13,ALRH,BHR1,MGC116786,MGC116788,MGC116789,P600,Interleukin-13

IL-13 Protein Products

Cat No Species Product Description
IL3-H4269HumanHuman IL-13 Protein, Fc Tag
IL3-H4217HumanHuman IL-13 Protein, Tag Free

IL-13 Molecule Background

Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.

Reference

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