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Bulk Recombinant Proteins --->Leukocyte Surface Antigen CD47

Leukocyte Surface Antigen CD47  


CD47,or Integrin-associated protein (IAP), is first discovered in a study aimed at studying integrin αvβ3. It turned out to be associated in cis with integrin αvβ3 on the cell membrane. Followup studies has established CD47 as the quintessential "marker of self" expressed in all cell types. It's a key regulator of tissue homeostasis, and is also involved in a variety of diseases ranging from atherosclerosis to cancer. CD47 protects the host cells by suppressing phagocytosis. It's well established that cancer cell-expressed CD47 interacts with the NK cell-expressed SIRP family proteins, SIRP alpha and SIRP gamma. By so doing, it protects the cancer cell from being eliminated by the innate immune response.

cd47-gene3.jpg

In addition, CD47 is also essential for TSP-1 mediated vascular NO signaling. It regulates CD36 and VEGFR2 to inhibit angiogenesis. Long term dysregulation of NO signaling is a hallmark for several types of cardiovascular diseases, which makes CD47 a promissing target for atherosclerosis. Indeed, Anti-CD47 mAb has been demonstrated to reduce the atherosclerotic burden in several in vivo models.

Given its significant role in pathogenesis of cancer and cardiovascular diseases, there is no surprise that CD47 signaling has been heavily investigated for new targeted therapeutics. ACROBiosystems provides a unique set of CD47-relevant products, including mutilple avi tag pre-biotinylated proteins, for rapid high throughput screening. The following pairs of products can be easily adapted to ELISA, Alphalisa, and MSD platform to screen neutralizing compound.

Suggested Pairs

Cat. No. Product Description Structure Purity Features
Pair 1 CD7-H82F6 Biotinylated Human CD47, Fc Tag, Avi Tag CD7-H82F6-STC1
CD7-H82F6-E1.jpg
SIA-H5225 Human SIRP alpha (HPLC-verified) SIA-H5225-STC1
SIA-H5225.jpg
SIA-H5225-E1.jpg
Pair 2 CD7-H82E9 Biotinylated Human CD47, Avi Tag CD7-H82E9-STC1
CD7-H82E9.jpg
CD7-H82E9-E1.jpg
SIA-H5251 Human SIRP alpha, Fc Tag (HPLC-verified) SIA-H5251-STC1
SIA-H5251.jpg
SIA-H5251-E1.jpg
Pair 3 CD7-H5227 Human CD47 Protein CD7-H5227
CD7-H5227-E1.jpg
CDA-H82F2 Biotinylated Human SIRP alpha, Fc, Avi Tag CDA-H82F2-STC1
CDA-H82F2-E1.jpg

>Click to view other biotinylated proteins from ACRO.

We also offer mouse Fc tagged CD47 and SIRP alpha in case human Fc-tag interferes with your assay design. These products are uniquely suitable to bind with humanized antibodies.

Molecule Cat. No. Product Description Structure Purity Features
CD47 CD7-H52A5 Human CD47, mouse IgG2a Fc Tag, low endotoxin CD7-H52A5-STC1
CD7-H52A5-E1.jpg
SIRP alpha SIA-H52A8 Human SIRP alpha, mouse IgG1 Fc Tag (HPLC-verified) SIA-H52A8-STC1
SIA-H52A8-E1.jpg

In addition, we also provide CD47 from other commonly used experimental animal species.

Cat. No. Species Product Description Structure Purity
CD7-C5252 Cynomolgus CD47 Protein, Fc Tag CD7-C5252-STC1
CD7-R5257 Rabbit CD47 Protein, Fc Tag CD7-R5257-STC1
CD7-R5256 Rat CD47 Protein, Fc Tag CD7-R5256-STC1
CD7-M5251 Mouse CD47 Protein, Fc Tag CD7-M5251-STC1