Browse Products By Molecule:

This web search service is supported by Google Inc.

Bulk Recombinant Proteins --->TIGIT Signaling Axis

TIGIT Signaling Axis  


TIGIT (T cell immununo receptor with lg and ITIM domains) is a newly discovered immune checkpoint protein expressed on T cells and Natural Killer cells (NK). TIGIT is an inhibitory receptor which modulates the immune activity by competing with activating receptor CD226 (also known as DNAM-1) for ligand binding. This on and off switch of TIGIT & DNAM-1 parallels that of CTLA4 & CD28, which makes it a promising target for anti-tumor therapy.

CD155 (PVR) and CD112 (PVRL2 or Nectin-2) are co-ligands of TIGIT and DNAM-1, while CD113 (PVRL3 or Nectin-3) is only binding to TIGIT. The affinity between different ligands and receptors vary. The binding between TIGIT and CD155 is more robust than that between TIGIT and CD112 or CD113.

tigit-antigen.png

ACROBiosystems carries a large collection of recombinant proteins from TIGIT signaling axis. In addition to the commonly used his and Fc tagged proteins, we also carry multiple pre-biotinylated proteins such as Biotinylated Human TIGIT, Avi Tag (Avitag™) (Cat. No. TIT-H82E5), Biotinylated Human CD155 / PVR Protein, Fc Tag, Avi Tag (Avitag™) (Cat. No. CD5-H82F6) and Biotinylated Human Nectin-2 / CD112 Protein, Fc Tag, Avi Tag (Avitag™) (Cat. No. CD2-H82F8). Please find detailed information below:

Product Highlight

CD5-H5251-E1.jpg
Immobilized Human CD155, Fc Tag (Cat. No. CD5-H5251) at 10μg/mL (100 μL/well) can bind Biotinylated Human TIGIT, His Tag (Cat. No. TIT-H82E5) with a linear range of 0.08-0.31 μg/mL (QC tested).

Request for protocol

TIGIT Product List

Cat. No. Species Product Description Structure Purity Features
TIT-H82E5
(Biotin-labeled)
Human Biotinylated Human TIGIT Protein, Avi Tag TIT-H82E5-STC1
TIT-H82E5.jpg
TIT-H82E5-E1.jpg
TIT-H82F1
(Biotin-labeled)
Human Biotinylated Human TIGIT Protein, Fc Tag, Avi Tag TIT-H82F1-STC1
TIT-H82F1.jpg
TIT-H82F1-E1.jpg
TIT-C5223 Cynomolgus Cynomolgus / Rhesus macaque TIGIT Protein TIT-C5223-STC1
TIT-C5223.jpg
TIT-C5223-E1.jpg
TIT-C5254 Cynomolgus Cynomolgus / Rhesus macaque TIGIT Protein, Fc Tag TIT-C5254-STC1
TIT-C5254-E1.jpg
TIT-M52E6 Mouse Mouse TIGIT Protein TIT-M52E6-STC1
TIT-M52E6.jpg
TIT-M5257 Mouse Mouse TIGIT Protein, Fc Tag TIT-M5257-STC1
TIT-M5257.jpg
TIT-M5257-E1.jpg
TIT-R5258 Rat Rat TIGIT Protein, Fc Tag TIT-R5258-STC1
TIT-R5258.jpg
TIT-R5258-E1.jpg
TIT-R5259 Rabbit Rabbit TIGIT Protein, Fc Tag TIT-R5259-STC1
TIT-R5259.jpg
TIT-H52H3 Human Human TIGIT Protein TIT-H52H3-STC1
TIT-H52H3.jpg
TIT-H52H3-E1.jpg
TIT-H5253 Human Human TIGIT Protein, Mouse IgG2a Fc Tag, low endotoxin TIT-H5253-STC1
TIT-H5253-E1.jpg
TIT-H5254 Human Human TIGIT Protein, Fc Tag TIT-H5254-STC1
TIT-H5254-E1.jpg

Other Relevant Products

Molecule Species Cat. No. Product Description Structure Purity Features
CD155 Human CD5-H82F6 Biotinylated Human CD155 / PVR Protein, Fc, Avi Tag CD5-H82F6-STC1
CD5-H82F6.jpg
CD5-H82F6-E1.jpg
CD112 Human CD2-H82F8 Biotinylated Human Nectin-2 / CD112 Protein, Fc, Avi Tag CD2-H82F8-STC1
CD2-H82F8.jpg
CD2-H82F8-E1.jpg
CD113 Human PV3-H82F3 Biotinylated Human Nectin-3 / CD113 Protein, Fc, Avi Tag PV3-H82F3-STC1
PV3-H82F3.jpg
PV3-H82F3-E1.jpg
DNAM-1 Human DN1-H82F9 Biotinylated Human DNAM-1 / CD226 Protein, Fc, Avi Tag DN1-H82F9-STC1
DN1-H82F9.jpg
DN1-H82F9-E1.jpg