Browse Products By Molecule:

This web search service is supported by Google Inc.

Bulk Recombinant Proteins --->B-Cell Maturation Antigen (BCMA), a Target for Multiple Myeloma

B-Cell Maturation Antigen (BCMA), a Target for Multiple Myeloma  


BCMA is selectively induced during plasma cell differentiation and is nearly absent on naive and memory B cells (Avery et al., 2003; Chiu et al., 2007). The interaction between BCMA and its ligand BAFF and APRIL is involved for the maintenance of long-lived plasma cells (O'Connor et al., 2004; Peperzak et al., 2013). BCMA is an ideal target for cancers of plasma cells, because it’s not expressed in other major organs. Dozens of BCMA-targeting therapies, including chimeric antigen receptor T (CAR-T) cells, antibody-drug conjugate, and Bi-specific antibodies, are currently being developed and tested clinically. Leading the pack is Bluebird and Celgene’s bb2121. A phase I multi-center clinical trial has demonstrated a stunning 80% response rate in multiple myeloma patients. These approaches, if successfully established, will bring multiple myeloma patients a much needed option beyond Daratumumab (anti-CD38 antibody) and Elotuzumab (anti-SLAMF7).

BCMA-LP.jpg

The interactions between BAFF / APRIL and their receptors are selective. Note BCMA can interact with both BAFF and APRIL (Bolkun et al., 2016). The affinity of APRIL-BCMA interaction, however, is much higher than that of BAFF-BCMA binding (Bossen and Schneider, 2006).



ACROBiosystems provides a comprehensive panel of BCMA proteins, including the exclusive biotinylated BCMA (Cat. No. BC7-H82F0) and the monomeric BCMA (Cat. No. BCA-H522y). We also offer BCMA related proteins, such as BAFF and BAFFR proteins.

Product Highlight

BAF-H4268-E2.jpg
Fig. 1 Immobilized Human BAFF, Fc Tag (Cat. No. BAF-H4268) at 5 μg/mL (100 μL/well) can bind Biotinylated Human BCMA, Fc Tag (Cat. No. BC7-H82F0) with a linear range of 0.12-1.95 ng/mL.
BCMA-purity.png
Fig. 2 The purity of Human BCMA, His Tag (Cat. No. BCA-H522y) is greater than 93% as determined by SEC-HPLC.

We offer a variety of ready-to-use biotinylated proteins using our in-house developed labeling techniques, which confer high bioactivity and minimal batch-to-batch variation. In addition, we also offer FITC-labeled BCMA and BAFF proteins.

BCMA Product List

Molecule Cat. No. Species Structure Purity Features
BCMA
(Biotin-labeled)
BC7-H82F0 Human BC7-H82F0-STC1
BC7-H82F0.jpg
BC7-H82F0-E1.jpg
BCMA
(Biotin-labeled)
BCA-C82F4 Cynomolgus BCA-C82F4-STC1
BCA-C82F4.jpg
BCA-C82F4-E1.jpg
BCMA
(FITC-Labeled)
BCA-HF254 Human BCA-HF254-STC1
BCA-HF254.jpg
BCA-HF254-E1.jpg
BCMA BCA-H522y Human BCA-H522y-STC1
BCA-H522y.jpg
BCA-H522y-E1.jpg
BCMA BC7-H5254 Human BC7-H5254-STC1
BC7-H5254.jpg
BC7-H5254-E1.jpg
BCMA BCA-C5253 Cynomolgus BCA-C5253-STC1
BCA-C5253.jpg
BCA-C5253-E1.jpg

Other Relevant Products

Molecule Cat. No. Species Structure Purity Features
BAFF
(Biotin-labeled)
BAF-H82F3 Human BAF-H82F3-STC1
BAF-H82F3.jpg
BAF-H82F3-E1.jpg
BAFF
(Biotin-labeled)
BAF-H82Q2 Human BAF-H82Q2-STC1
BAF-H82Q2.jpg
BAF-H82Q2-E1.jpg
BAFF
(FITC-Labeled)
BAF-HF268 Human BAF-HF268-STC1
BAF-HF268.jpg
BAF-HF268-E1.jpg
BAFF BAF-H4218 Human BAF-H4218-STC1
BAF-H4218.jpg
BAF-H4218-E1.jpg
BAFF BAF-H4268 Human BAF-H4268-STC1
BAF-H4268.jpg
BAF-H4268-E1.jpg
BAFF BAF-H5248 Human BAF-H5248-STC1
BAF-H5248.jpg
BAF-H5248-E1.jpg
BAFFR
(Biotin-labeled)
BAR-M82F0 Human BAR-M82F0-STC1
BAR-M82F0.jpg
BAR-M82F0-E1.jpg
BAFFR BAR-M5259 Human BAR-M5259-STC1
BAR-M5259.jpg
BAR-M5259-E1.jpg
BAFFR BAR-H5257 Human BAR-H5257-STC1
BAR-H5257.jpg
BAR-H5257-E1.jpg

Other Multiple Myeloma Targets

Molecule Cat. No. Species Structure Purity Features
CD38
(Biotin-labeled)
CD8-H82E7 Human CD8-H82E7-STC1
CD8-H82E7.jpg
CD8-H82E7-E1.jpg
CD38 CD8-H5224 Human CD8-H5224-STC1
CD8-H5224.jpg
CD8-H5224-E1.jpg
SLAMF7
(Biotin-labeled)
SL7-H82E0 Human SL7-H82E0-STC1
SL7-H82E0.jpg
SLAMF7 SL7-H5225 Human SL7-H5225-STC1
SL7-H5225.jpg
SLAMF7 SL7-H5256 Human SL7-H5256-STC1
SL7-H5256.jpg