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Bulk Recombinant Proteins --->Biotinylated CD3E & more CD3 products

Biotinylated CD3E & more CD3 products  


The T-cell receptor (TCR) does not signal on its own. Instead, it is constitutively associated with the CD3 coreceptors, which contain intracellular signaling apparatus, consisting of the CD3εγ and CD3εδ heterodimers and the CD3ζζ homodimer (Wucherpfennig KW, et al., 2010; Kuhns MS, et al., 2012). CD3 has become a focal point of pharmaceutical research in the last decades. Direct inhibition of CD3 protein has been used to treat autoimmune diseases and allograft rejection. OKT3, the first mouse monoclonal antibody specific for human CD3, was produced in 1979 by P. Kung and G. Goldstein (Kung P, et al., 1979). It was also the first monoclonal antibody to be used in clinical practice, in the field of transplantation.

More recently, targeting CD3 has been used as a strategy to bridge cytotoxic T cells to target cells in bi-specific antibody design. A successful example is Amgen’s Blincyto® (blinatumomab). Blinatumomab is a bi-specific antibody simultaneously targeting CD3 and CD19, and by so doing directing the CD3-expressing T cells to CD19-expressing lymphoma cells (Nagorsen D, et al., 2012). The capacity of CD3-specific antibody therapy to promote tolerance, a concept that has been proven for autoimmune diabetes, could be extended to other autoimmune diseases and transplantation.

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ACROBiosystems provides a comprehensive panel of CD3 proteins, including the exclusive Biotinylated Human CD3 epsilon (Cat. No. CDE-H8223), and the Biotinylated Human CD3E & CD3D heterodimer protein (Cat. No. CDD-H82W0). We are also the only supplier for Mouse CD3 epsilon protein (Cat. No. CDE-M5256).

CD3 Product Highlight

CDE-H8223-E1.jpg
Immobilized Anti-Human CD3 Mab, mouse IgG1 (Clone # SP34-2) at 2 μg/mL (100 μL/well) can bind Biotinylated Human CD3E, His Tag (Cat. No. CDE-H8223) with a linear range of 0.05-2 ng/mL.
CDD-H82W0-E1.jpg
Immobilized Biotinylated Human CD3E & CD3D (Cat. No. CDD-H82W0) can bind OKT3 with a linear range of 2-39 ng/mL. The biotinylated CD3E & CD3D heterodimers are coated at 1 ug/mL (100 μL/well) on a streptavidin coated plates.

CD3 Product List

Molecule Cat. No. Species Structure Purity Features
CD3 epsilon
(Biotin-labeled)
CDE-H8223 Human CDE-H8223-STC1
CDE-H8223.jpg
CDE-H8223-E1.jpg
CD3 epsilon CDE-H5223 Human CDE-H5223-STC1
CDE-H5223.jpg
CDE-H5223-E1.jpg
CD3 epsilon CDE-H5256 Human CDE-H5256-STC1
CDE-H5256.jpg
CDE-H5256-E1.jpg
CD3 epsilon CDE-H5286 Human CDE-H5286-STC1
CDE-H5286.jpg
CDE-H5286-E1.jpg
CD3 epsilon CDE-M5256 Mouse CDE-M5256-STC1
CDE-M5256.jpg
CD3 epsilon CDE-C5226 Cynomolgus CDE-C5226-STC1
CDE-C5226.jpg
CDE-C5226-E1.jpg
CD3 epsilon CDE-C5254 Cynomolgus CDE-C5254-STC1
CDE-C5254.jpg
CDE-C5254-E1.jpg
CD3 delta CDD-H5224 Human CDD-H5224-STC1
CDD-H5224.jpg
CD3 delta CDD-C52H8 Cynomolgus CDD-C52H8-STC1
CDD-C52H8.jpg
CD3E & CD3D
(Biotin-labeled)
CDD-H82W0 Human CDD-H82W0-STC1
CDD-H82W0.jpg
CDD-H82W0-E1.jpg
CD3E & CD3D CDD-H52W4 Human CDD-H52W4-STC1
CDD-H52W4.jpg
CDD-H52W4-E1.jpg
CD3E & CD3D CDD-H52W0 Human CDD-H52W0-STC1
CDD-H52W0.jpg
CDD-H52W0-E1.jpg
CD3E & CD3D CDD-C52W4 Cynomolgus CDD-C52W4-STC1
CDD-C52W4.jpg
CDD-C52W4-E1.jpg
CD3E & CD3G CDG-H52W9 Human CDG-H52W9-STC1
CDG-H52W9.jpg
CDG-H52W9-E1.jpg

Related products

Molecule Cat. No. Species Structure Purity Features
CD4
(Biotin-labeled)
CD4-H82E8 Human CD4-H82E8-STC1
CD4-H82E8.jpg
CD4-H82E8-E1.jpg
CD4
(Biotin-labeled)
CD4-H82F3 Human CD4-H82F3-STC1
CD4-H82F3.jpg
CD4-H82F3-E1.jpg
CD4 LE3-H5228 Human LE3-H5228-STC1
LE3-H5228.jpg
LE3-H5228-E1.jpg
CD4 CD4-H5259 Human CD4-H5259-STC1
CD4-H5259.jpg
CD4-H5259-E1.jpg
CD4 CD4-C52H7 Rhesus macaque CD4-C52H7-STC1
CD4-C52H7.jpg
CD4 CD4-C5256 Rhesus macaque CD4-C5256-STC1
CD4-C5256.jpg
CD4-C5256-E1.jpg