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Browse By Molecule Name --->CD155 / PVR / TAGE4 Molecule

CD155 / PVR / TAGE4 Molecule  

CD155 / PVR Molecule Synonym Name


CD155 / PVR Protein Products

Cat No Species Product Description
CD5-H5223HumanHuman CD155 / PVR Protein
CD5-H5251HumanHuman CD155 / PVR Protein, Fc Tag
CD5-H82F6HumanBiotinylated Human CD155 / PVR Protein, Fc Tag, Avi Tag (Avitag?)
CD5-H5254HumanHuman CD155 / PVR Protein, Mouse IgG2a Fc Tag, low endotoxin

CD155 / PVR Molecule Background

CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155/PVR was originally isolated based on its ability to mediate polio virus attachment to host cells. The fulllength (or CD155 alpha isoform) is synthesized as a 417 amino acid (aa) precursor that contains a 20 aa signal sequence, a 323 aa extracellular region, a 24 aa TM segment and a 50 aa cytoplasmic tail. The extracellular region contains one N terminal V type and two C2 type Ig like domains. CD155 is a transmembrane protein with 3 extracellular immunoglobulin-like domains, D1-D3, where D1 is recognized by the virus. Low resolution structures of CD155 complexed with poliovirus have been obtained using electron microscopy while a high resolution structures of theectodomain D1 and D2 of CD155 were solved by x-ray crystallography.


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