Contactin-2 Molecule Synonym Name
Contactin-2 Protein Products
|Cat No||Species||Product Description|
|CN2-H5226||Human||Human Contactin-2 / Tag1 / CNTN2 Protein|
Contactin-2 Molecule Background
Contactin-2 is also known as CNTN2, TAX1 (transiently-expressed axonal glycoprotein), TAG1 (transient axonal glycoprotein), and axonin-1, and is a member of the immunoglobulin superfamily. CNTN2 consists of six Ig-like domains and four fibronectin type III domains, and is anchored to the membrane by glycosylphosphatidylinositol (GPI), whereas the soluble form can be released by a GPI-specific phospholipase. As a neural cell adhesion molecule expressed by a subset of neuronal populations in the developing CNS and PNS, CNTN2 mediates cell-cell interactions either via homophilic, or heterophilic contacts with various adhesion molecules including NgCAM, NrCAM, NCAM and neurocan. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention.
- (1) Tsiotra PC, et al., 1993, Genomics 18 (3): 562–7. .
- (2) Traka, M. et al., 2003, J. Cell. Biol. 162: 1161-1172.
- (3) M?rtl M, ET AL., 2007, Protein Sci.16(10):2174-83.