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Your Position: Home > CSF1R / CD115 / M-CSFR Molecule

CSF1R / CD115 Molecule Synonym Name

CSF1R,C-FMS,CD115,CSFR,FIM2,FMS,M-CSFR

CSF1R / CD115 Protein Products

Cat No Species Product Description
CSR-C5252 Cynomolgus Cynomolgus M-CSF R / CSF1R / CD115 Protein, Fc Tag
CSR-C52E1 Cynomolgus Cynomolgus M-CSF R / CSF1R / CD115 Protein
CSR-H5228 Human Human M-CSF R / CSF1R / CD115 Protein
CSR-H5258 Human Human M-CSF R / CSF1R / CD115 Protein, Fc Tag, low endotoxin
CSR-M5256 Mouse Mouse M-CSF R / CSF1R / CD115 Protein, Fc Tag, low endotoxin
CSR-M52E7 Mouse Mouse M-CSF R / CSF1R / CD115 Protein
CSR-M82E8 Mouse Biotinylated Mouse M-CSF R / CSF1R / CD115 Protein, His Tag & Avi Tag (Avitag™)

CSF1R / CD115 Molecule Background

Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.

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