CADM1 / IGSF4A / NECL2 Molecule
CADM1 / IGSF4A Molecule Synonym Name
CADM1 / IGSF4A Protein Products
|Cat No||Species||Product Description|
|CA1-H5225||Human||Human CADM1 / IGSF4A Protein|
CADM1 / IGSF4A Molecule Background
Cell Adhesion Molecules (CAMs) are proteins located on the cell surface involved with the binding with other cells or with the extracellular matrix (ECM) in the process called cell adhesion. Cell adhesion molecule 1 is a single-pass type I membrane protein which belongs to the?nectin family. Cell Adhesion Molecule 1 contains two?Ig-like C2-type (immunoglobulin-like) domains and one?Ig-like V-type (immunoglobulin-like) domain, and is also known as CADM1; BL2; DKFZp686F1789; IGSF4; IGSF4A; MGC149785; MGC51880; NECL2; Necl-2; RA175; ST17; SYNCAM; TSLC1; sTSLC-1; sgIGSF; synCAM1. CADM1 mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner. CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. CADM1 may be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. CADM1 may play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
- (1) Kuramochi M. 2001, Nat. Genet. 27: 427-430 .
- (2) Yageta M. et al., 2002, Cancer Res. 62: 5129-5133.
- (3) Furuno T. et al., 2005, J. Immunol. 174: 6934-6942.
- (4) Boles KS. et al., 2005, Blood. 106: 779-786.
- (5) Dong X. et al., 2006? J. Biol. Chem. 281: 10610-7.