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DKK1 Molecule  


Dkk-1 Molecule Synonym Name

DKK1,SK

Dkk-1 Protein Products

Cat No Species Product Description
DK1-H5221 Human Human Dkk-1 Protein
DK1-H5258 Human Human Dkk-1 Protein, Fc Tag
DK1-H5286 Human Human Dkk-1 Protein, Strep Tag
DK1-M52H6 Mouse Mouse Dkk-1 Protein

Dkk-1 Molecule Background

Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.

Reference

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