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DPPIV / CD26 Molecule  


DPPIV / CD26 Molecule Synonym Name

DPP4,ADABP,ADCP2,CD26,DPPIV,TP103

DPPIV / CD26 Protein Products

Cat No Species Product Description
DP4-H5211HumanHuman DPPIV / CD26 Protein, Tag Free
DP4-H5221HumanHuman DPPIV / CD26 Protein
DP4-H5266HumanHuman DPPIV / CD26 Protein, Fc Tag

DPPIV / CD26 Molecule Background

Dipeptidyl peptidase-IV (DPPIV) is also known as adenosine deaminase complexing protein 2, DPPIV or CD26 is antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPPIV are proline (or alanine)-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPPIV plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. DPPIV plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others. DPPIV also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.

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