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EGFR / ErbB1 / HER1 Molecule  


EGF R Molecule Synonym Name

EGFR,ERBB,ERBB1,HER1,PIG61,mENA

EGF R Protein Products

Cat No Species Product Description
EGI-H52H4HumanHuman EGFRvIII Protein
EGR-C5252Rhesus macaqueRhesus macaque EGF R Protein, Fc Tag
EGR-C52H1Rhesus macaqueRhesus macaque EGF R Protein
EGR-H5222HumanHuman EGF R Protein
EGR-H5252HumanHuman EGF R Protein, Fc Tag
EGR-H5285HumanHuman EGF R Protein, Strep Tag
EGR-H82E0HumanBiotinylated Human EGFRvIII, Avi Tag (Avitag?)
EGR-H82E7HumanBiotinylated Human EGF R, Avi Tag (Avitag?)
EGR-H9222HumanC13 and N15-labeled, Human EGF R Protein
EGR-M5224MouseMouse EGF R Protein

EGF R Molecule Background

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer. The type III EGF deletion-mutant receptor (EGFRvIII) is the most common mutation and was first identified in primary human glioblastoma tumors; EGFR gene amplification is correlated with the structural rearrangement of the gene. The EGFRvIII gene has an in-frame deletion of 801 base pairs, corresponding to exons 2–7 in the mRNA, resulting in the deletion of amino acids 30-297 in the extracellular domain and the generation of a glycine at the fusion point

Reference

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