EpCAM / CD326 / TACSTD1 Molecule
EpCAM / TROP1 Molecule Synonym Name
EpCAM / TROP1 Protein Products
|Cat No||Species||Product Description|
|EPM-C5227||Rhesus macaque||Rhesus macaque EpCAM / TROP1 Protein|
|EPM-H5223||Human||Human EpCAM / TROP1 Protein|
|EPM-H5254||Human||Human EpCAM / TROP1 Protein, Fc Tag|
|EPM-H5283||Human||Human EpCAM / TROP1 Protein, Strep Tag|
|EPM-H8223||Human||Biotinylated Human EpCAM / TROP1, ultra sensitivity (primary amine labeling)|
|EPM-H8254||Human||Biotinylated Human EpCAM / TROP1, Fc Tag, ultra sensitivity (primary amine labeling)|
|EPM-M5227||Mouse||Mouse EpCAM / TROP1 Protein|
EpCAM / TROP1 Molecule Background
EpCAM is also known as CO171A,; EGP; EGP40; GA7332; KSA; M4S; MIC18; MK1; TROP1; hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.
- (1) Linnenbach, et al., 1993, Mol Cell Biol 13 (3): 1507–15.
- (2) Akita H, et al., 2011, Oncogene., 30 (31): 3468-76.
- (3) Winter MJ, et al., 2007, Mol Cell Biochem. 302(1-2):19-26.
- (4) Schmidt M, et al., 2011, Breast Cancer Res Treat. 125(3):637-46.