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Your Position: Home > ErbB2 / HER2 Molecule

Her2 / ErbB2 Molecule Synonym Name

ERBB2,CD340,HER-2/neu,HER2,MLN19,NEU,NGL,TKR1

Her2 / ErbB2 Protein Products

Cat No Species Product Description
ER2-M5220 Mouse Mouse Her2 / ErbB2 Protein
HE2-H521y Human Human Her2 / ErbB2 Protein, Tag Free
HE2-H5225 Human Human Her2 / ErbB2 Protein
HE2-H5253 Human Human Her2 / ErbB2 Protein, Fc Tag
HE2-H525x Human Human Her2 / ErbB2 (23-450) Protein, Fc Tag
HE2-H5287 Human Human Her2 / ErbB2 Protein, Strep Tag
HE2-H822R Human Biotinylated Human Her2 / ErbB2, ultra sensitivity (primary amine labeling, long spacer)
HE2-H9225 Human C13 and N15-labeled, Human Her2 / ErbB2 Protein

Her2 / ErbB2 Molecule Background

Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2/neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer,communication at the neuromuscular junction andregulation of cell growth and differentiation.

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