ErbB2 / HER2 Molecule
Her2 / ErbB2 Molecule Synonym Name
Her2 / ErbB2 Protein Products
|Cat No||Species||Product Description|
|ER2-M5220||Mouse||Mouse Her2 / ErbB2 Protein|
|HE2-H521y||Human||Human Her2 / ErbB2 Protein, Tag Free|
|HE2-H5225||Human||Human Her2 / ErbB2 Protein|
|HE2-H5253||Human||Human Her2 / ErbB2 Protein, Fc Tag|
|HE2-H525x||Human||Human Her2 / ErbB2 (23-450) Protein, Fc Tag|
|HE2-H5287||Human||Human Her2 / ErbB2 Protein, Strep Tag|
|HE2-H822R||Human||Biotinylated Human Her2 / ErbB2, ultra sensitivity (primary amine labeling, long spacer)|
|HE2-H9225||Human||C13 and N15-labeled, Human Her2 / ErbB2 Protein|
Her2 / ErbB2 Molecule Background
Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2/neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer,communication at the neuromuscular junction andregulation of cell growth and differentiation.
- (1) Kanai, Y. et. al., 1995, Biochem. Biophys. Res. Commun.208:1067.
- (2) Codony-Seeervat, J. et al., 1999, Cancer Res. 59: 1196-1201.
- (3) Tzahar, E. et al., 1998, Biochim. Biophys. Acta. 1377: 25-37.
- (4) Kermit, L. et al, 1999, J. Biol. Chem. 274: 5263-5266.
- (5) Hellyer, N.J. et. al., 2001, J. Biol. Chem. 276:42153.
- (6) Daly, R.J., 1999, Growth Factors 16:255.