FOLR1 Molecule Synonym Name
FOLR1 Protein Products
|Cat No||Species||Product Description|
|FO1-H5229||Human||Human FOLR1 Protein|
|FO1-H528b||Human||Human FOLR1 Protein, Strep Tag|
|FO1-M5225||Mouse||Mouse FOLR1 Protein|
|FO1-M82E9||Mouse||Biotinylated Mouse FOLR1 Protein, Avi Tag (Avitag™)|
FOLR1 Molecule Background
Folate Receptor 1 (FOLR1) is also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.
- (1) Lacey SW, et al., 1989, J. Clin. Invest. 84 (2): 715–20.
- (2) Elwood PC, 1989, J. Biol. Chem. 264 (25): 14893–901.
- (3) Rijnboutt, S. et al., 1996, J. Cell Biol. 132:35.
- (4) Parker, N. et al., 2005, Anal. Biochem. 338:284.
- (5) Paulos C M, et al., 2004, Mol Pharmacol. 2004;66:1406–1414.
- (6) Elwood PC., et al., 1991, J Biol Chem., 266(4): 2346-2353.
- (7) Dainty,L.A. et al., 2007, Gynecol Oncol. 105 (3):563-70.