IL-33 / NF-HEV Molecule
IL-33 Molecule Synonym Name
IL-33 Protein Products
|Cat No||Species||Product Description|
|IL3-H4112||Human||Human IL-33 Protein, Tag Free|
IL-33 Molecule Background
Interleukin 33 (IL33) is known as C9orf26, DKFZp586H0523, DVS27, NF-HEV, NFEHEV, RP11-575C20.2,and is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.
- (1) Lingel A,et al.2009, Structure 17 (10): 1398–410.
- (2) Dinarello CA., 2005, Immunity, 23(5):461-2.