KIM1 / TIM1 / HAVCR1 Molecule
TIM-1 / HAVCR1 Molecule Synonym Name
TIM-1 / HAVCR1 Protein Products
|Cat No||Species||Product Description|
|KI1-H5227||Human||Human TIM-1 / KIM-1 / HAVCR1 Protein|
TIM-1 / HAVCR1 Molecule Background
Hepatitis A virus cellular receptor 1 is also known as HAVCR1, HAVCR, KIM1, TIM, TIM1, TIMD1, is widely expressed with highest levels in kidney and testis. The protein encoded by HAVCR1 gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Three transcript variants encoding the same protein have been found for this gene. HAVCR1 may play a role in T-helper cell development, the regulation of asthma and allergic diseases and in kidney injury and repair. In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus.
- (1) Silberstein, E. et al., 2001, J Virol.??75?(2): 717-25.
- (2) Silberstein, E. et al., 2003, J Virol.??77?(16): 8765-74.
- (3) McIntire JJ, et al. 2001, Nat Immunol 2 (12): 1109–16.