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KIM3 / HAVCR2 / TIM3 Molecule  

TIM-3 / HAVCR2 Molecule Synonym Name


TIM-3 / HAVCR2 Protein Products

Cat No Species Product Description
KI3-H5252HumanHuman TIM-3 / HAVCR2 (22-142) Protein, Fc Tag
TI3-H5285HumanHuman TIM-3 / HAVCR2 (22-200) Protein, Strep Tag
TI3-M5252MouseMouse TIM-3 / HAVCR2 Protein, Fc Tag
TI3-M52H1MouseMouse TIM-3 / HAVCR2 Protein
TM3-H5229HumanHuman TIM-3 / HAVCR2 Protein
TM3-H5258HumanHuman TIM-3 / HAVCR2 (22-200) Protein, Fc Tag

TIM-3 / HAVCR2 Molecule Background

Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428,? KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.


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