KIM3 / HAVCR2 / TIM3 Molecule
TIM-3 / HAVCR2 Molecule Synonym Name
TIM-3 / HAVCR2 Protein Products
|Cat No||Species||Product Description|
|KI3-H5252||Human||Human TIM-3 / HAVCR2 (22-142) Protein, Fc Tag|
|TI3-H5285||Human||Human TIM-3 / HAVCR2 (22-200) Protein, Strep Tag|
|TI3-M5252||Mouse||Mouse TIM-3 / HAVCR2 Protein, Fc Tag|
|TI3-M52H1||Mouse||Mouse TIM-3 / HAVCR2 Protein|
|TM3-H5229||Human||Human TIM-3 / HAVCR2 Protein|
|TM3-H5258||Human||Human TIM-3 / HAVCR2 (22-200) Protein, Fc Tag|
TIM-3 / HAVCR2 Molecule Background
Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428,? KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.
- (1) Monney, L. et al., 2002, Nature. 415: 536-41.
- (2) Sabatos, CA. et al., 2003, Nat. Immunol. 4: 1102-10.
- (3) Anderson, AC. et al., 2006, Curr. Opin. Immunol. 18: 665-9.