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Browse By Molecule Name --->LIFR / CD118 Molecule

LIFR / CD118 Molecule  


LIF R / CD118 Molecule Synonym Name

LIFR,CD118,FLJ98106,FLJ99923,SJS2,STWS,SWS

LIF R / CD118 Protein Products

Cat No Species Product Description
LIR-H4252HumanHuman LIF R / CD118 Protein, Fc Tag

LIF R / CD118 Molecule Background

Leukemia inhibitory factor receptor is also known as LIFR; CD118; FLJ98106; FLJ99923; LIF-R; SJS2; STWS; SWS, is the receptor for leukemia inhibitory factor (LIF). The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS), a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias.

Reference

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