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VEGFR2 / KDR / CD309 Molecule  


VEGF R2 / KDR Molecule Synonym Name

KDR,CD309,FLK1,VEGFR,VEGFR2

VEGF R2 / KDR Protein Products

Cat No Species Product Description
KDR-H5227HumanHuman VEGF R2 / KDR Protein (HPLC-verified)
KDR-H5280HumanHuman VEGF R2 / KDR Protein, Strep Tag
KDR-H82E5HumanBiotinylated Human VEGF R2 / KDR Protein, Avi Tag (Avitag?)
KDR-H9227HumanC13 and N15-labeled, Human VEGF R2 / KDR Protein
VE2-C52H3Rhesus macaqueRhesus macaque VEGF R2 / KDR Protein

VEGF R2 / KDR Molecule Background

Kinase insert domain receptor (KDR) is also known as CD309, FLK1, VEGFR, VEGFR2, and is one of the subtypes of VEGFR. VEGF receptors are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain. VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF.The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 may be to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding (this appears to be particularly important during vasculogenesis in the embryo). In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi's sarcoma lesions.

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