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CD70 / TNFSF7 / CD27-L Molecule  


CD27 Ligand / CD70 Molecule Synonym Name

CD70,CD27LG,TNFSF7,TNFSF7G,CD27L

CD27 Ligand / CD70 Protein Products

Cat No Species Product Description
TN7-H526xHumanHuman CD27 Ligand / CD70 Protein, Fc Tag

CD27 Ligand / CD70 Molecule Background

Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.

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