CD70 / TNFSF7 / CD27-L Molecule
CD27 Ligand / CD70 Molecule Synonym Name
CD27 Ligand / CD70 Protein Products
|Cat No||Species||Product Description|
|TN7-H526x||Human||Human CD27 Ligand / CD70 Protein, Fc Tag|
CD27 Ligand / CD70 Molecule Background
Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.
- (1) McEarchern JA. et al., 2008, Clin Cancer Res., 14(23):7763-72.
- (2) Croft M., 2003, Nat Rev Immunol., 3(8):609-20.
- (3) Kobata, TS. et al., 1995, Proc. Natl. Acad. Sci. USA, 92: 11249–11253.
- (4) Raman V.S. et al., 2003, J Immunol., 171(11):5876-81.
- (5) Takeda, K. et al., 2000, J Immunol., 15;164(4):1741-5.