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Browse By Molecule Name --->FASLG / CD178 Molecule

FASLG / CD178 Molecule  


Fas Ligand Molecule Synonym Name

FASLG,ALPS1B,APT1LG1,CD178,CD95L,FASL,TNFSF6

Fas Ligand Protein Products

Cat No Species Product Description
FAG-H9241HumanC13 and N15-labeled, Human Fas Ligand / TNFSF6 Protein
FAL-H5241HumanHuman Fas Ligand / TNFSF6 Protein

Fas Ligand Molecule Background

Fas ligand is also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Mature human Fas Ligand consists of a 179 amino acid (aa) extracellular domain (ECD), a 22 aa transmembrane segment, and a 80 aa cytoplasmic domain. Within the ECD, human Fas Ligand shares 81% and 78% aa sequence identity with mouse and rat Fas Ligand, respectively. Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include:T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.

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