PLAU / uPA Molecule
PLAU / uPA Molecule Synonym Name
PLAU / uPA Protein Products
|Cat No||Species||Product Description|
|PLU-H5229||Human||Human PLAU / uPA Protein|
PLAU / uPA Molecule Background
Urokinase - type plasminogen activator is also known as PLAU and UPA, a serine protease with an extremely limited substrate specificity, cleaving the sequence Cys – Pro – Gly - Arg560 - Val561 – Val – Gly – Gly – Cys in plasminogen to form plasmin. uPA is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.uPA and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction).
- (1) Nagai M., et al., 1985, Gene 36:183.
- (2) Jacobs P., et al., 1985, DNA 4:139.
- (3) Harbeck, N. et al., 2002, Clin. Breast Cancer 3:196.