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Browse By Molecule Name --->PLAU / uPA Molecule

PLAU / uPA Molecule  


PLAU / uPA Molecule Synonym Name

Urokinase,PLAU,ATF,UPA,URK,u-PA,BDPLT5,QPD

PLAU / uPA Protein Products

Cat No Species Product Description
PLU-H5229 Human Human PLAU / uPA Protein

PLAU / uPA Molecule Background

Urokinase - type plasminogen activator is also known as PLAU and UPA, a serine protease with an extremely limited substrate specificity, cleaving the sequence Cys – Pro – Gly - Arg560 - Val561 – Val – Gly – Gly – Cys in plasminogen to form plasmin. uPA is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.uPA and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction).

Reference

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