IL4R / CD124 Molecule
IL-4 R alpha / CD124 Molecule Synonym Name
IL-4 R alpha / CD124 Protein Products
|Cat No||Species||Product Description|
|ILR-C5258||Cynomolgus||Cynomolgus IL-4 R alpha / CD124 Protein, Fc Tag|
|ILR-C52H8||Cynomolgus||Cynomolgus IL-4 R alpha / CD124 Protein|
|ILR-H5221||Human||Human IL-4 R alpha / CD124 Protein|
|ILR-M5252||Mouse||Mouse IL-4 R alpha / CD124 Protein, Fc Tag|
|ILR-M52H1||Mouse||Mouse IL-4 R alpha / CD124 Protein|
|ILR-H82E9||Human||Biotinylated Human IL-4 R alpha / CD124 Protein, Avi Tag (Avitag?)|
IL-4 R alpha / CD124 Molecule Background
IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Rα (CD124)subunit and the 70 kDa common cytokine γc chain (CD132). Interleukin?4?Receptor (IL4R) also known as CD124, IL4Rα and?BSF?receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-?biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R?can?alternatively?associate?with?IL?13Ra1?to?form?the?type?II?receptor?which?is?responsive?to?both?IL?4?and?IL?13. Interleukin-4 receptor has been shown to interact with SHC1.
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