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Browse By Molecule Name --->IL4R / CD124 Molecule

IL4R / CD124 Molecule  


IL-4 R alpha / CD124 Molecule Synonym Name

IL4R,CD124,IL4RA

IL-4 R alpha / CD124 Protein Products

Cat No Species Product Description
ILR-C5258CynomolgusCynomolgus IL-4 R alpha / CD124 Protein, Fc Tag
ILR-C52H8CynomolgusCynomolgus IL-4 R alpha / CD124 Protein
ILR-H5221HumanHuman IL-4 R alpha / CD124 Protein
ILR-M5252MouseMouse IL-4 R alpha / CD124 Protein, Fc Tag
ILR-M52H1MouseMouse IL-4 R alpha / CD124 Protein
ILR-H82E9HumanBiotinylated Human IL-4 R alpha / CD124 Protein, Avi Tag (Avitag?)

IL-4 R alpha / CD124 Molecule Background

IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Rα (CD124)subunit and the 70 kDa common cytokine γc chain (CD132). Interleukin?4?Receptor (IL4R) also known as CD124, IL4Rα and?BSF?receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-?biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R?can?alternatively?associate?with?IL?13Ra1?to?form?the?type?II?receptor?which?is?responsive?to?both?IL?4?and?IL?13. Interleukin-4 receptor has been shown to interact with SHC1.

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