HMGB1 Molecule Synonym Name
HMGB1 Protein Products
|Cat No||Species||Product Description|
|HM1-H5220||Human||Human HMGB1 Protein|
HMGB1 Molecule Background
High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. The mechanism of inflammation and damage is binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release. This positions HMGB1 at the intersection of sterile and infectious inflammatory responses. HMGB1 has been studied as a DNA vaccine adjuvant and a target for cancer therapy.
- (1) Wang H, et al., 1999, Science 285 (5425): 248–51.
- (2) Yang H, et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107 (26): 11942–7.
- (3) Yang H, et al., 2010, Biochim. Biophys. Acta 1799 (1-2): 149–56.
- (4) Fagone P, et al., 2011, Gene Ther. 18 (11): 1070–7.