Decorin / DSPG2 Molecule
Decorin Molecule Synonym Name
Decorin Protein Products
|Cat No||Species||Product Description|
|DE1-H5223||Human||Human Decorin Protein|
Decorin Molecule Background
Decorin is also known as bone proteoglycan II, PGS2, SLRR1B, DCN, DSPG2 and PG40, is a secreted chondroitin /dermatan sulfate proteoglycan in the family of small leucine-rich proteoglycans (SLRPs). Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. Decorin and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. Decorin appears to influence fibrillogenesis, and also interacts with fibronectin, thrombospondin, the complement component C1q, epidermal growth factor receptor (EGFR) and transforming growth factor-beta (TGF-beta). Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD).
- (1) Santra, Manoranjan, et al., 2002, J. Biol. Chem. (United States) 277 (38): 35671–81.
- (2) Iozzo, R V., et al., 1999, J. Biol. Chem. (UNITED STATES) 274 (8): 4489–92.
- (3) Sch?nherr, E., et al., 1998, Arch. Biochem. Biophys. (UNITED STATES) 355 (2): 241–8.
- (4) Takeuchi, Y., et al., 1994, J. Biol. Chem. (UNITED STATES) 269 (51): 32634–8.