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Browse By Molecule Name --->TFPI / EPI Molecule

TFPI / EPI Molecule  

TFPI Molecule Synonym Name


TFPI Protein Products

Cat No Species Product Description
TFI-C52H3Rhesus macaqueRhesus macaque TFPI Protein
TFI-H5226HumanHuman TFPI Protein
TFI-H8226HumanBiotinylated Human TFPI, ultra sensitivity (primary amine labeling)

TFPI Molecule Background

Tissue factor pathway inhibitor (TFPI) is also known as Extrinsic pathway inhibitor (EPI), Lipoprotein - associated coagulation inhibitor (LACI), is a plasma proteinase inhibitor synthesized by vascular endothelial cells and part of it is associated with glycosaminoglycans of these cells. TFPI is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). TFPI is a secreted protein with a N?terminal acidic region, three Kunitz (K) domains separated with by two linker regions, and a C?terminal basic region. The first K domain inhibits coagulation factor VIIa complexed to tissue factor (TF); The second K domain inhibits factor Xa; The third K domain binds to heparin; The C?terminal basic region may have several functions. For example, it plays an important role in binding of TFPI to cell surfaces.


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