TFPI / EPI Molecule
TFPI Molecule Synonym Name
TFPI Protein Products
|Cat No||Species||Product Description|
|TFI-C52H3||Rhesus macaque||Rhesus macaque TFPI Protein|
|TFI-H5226||Human||Human TFPI Protein|
|TFI-H8226||Human||Biotinylated Human TFPI, ultra sensitivity (primary amine labeling)|
TFPI Molecule Background
Tissue factor pathway inhibitor (TFPI) is also known as Extrinsic pathway inhibitor (EPI), Lipoprotein - associated coagulation inhibitor (LACI), is a plasma proteinase inhibitor synthesized by vascular endothelial cells and part of it is associated with glycosaminoglycans of these cells. TFPI is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). TFPI is a secreted protein with a N?terminal acidic region, three Kunitz (K) domains separated with by two linker regions, and a C?terminal basic region. The first K domain inhibits coagulation factor VIIa complexed to tissue factor (TF); The second K domain inhibits factor Xa; The third K domain binds to heparin; The C?terminal basic region may have several functions. For example, it plays an important role in binding of TFPI to cell surfaces.
- (1) Bajaj MS., et al., 2001, Thromb Haemost., 86:959.
- (2) Mine S., et al., 2002, Biochemistry, 41:78.
- (3) Witt I., et al., 2002, Hamostaseologie, 22:30–35.