TFPI2 / PP5 Molecule
TFPI-2 Molecule Synonym Name
TFPI-2 Protein Products
|Cat No||Species||Product Description|
|TF2-H5227||Human||Human TFPI-2 Protein|
TFPI-2 Molecule Background
Tissue Factor Pathway Inhibitor 2 (TFPI?2) is also known as placental protein 5 (PP5) and retinal pigment epithelial cell factor 1 (REF?1), is a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). TFPI2 is highly abundant in the full-term placenta and widely expressed in umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy. TFPI?2 may play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa and has no effect on thrombin. Reduced synthesis of TFPI-2 has been related to numerous pathophysiological processes such as inflammation, angiogenesis, atherosclerosis, retinal degeneration and tumor growth / metastasis.
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