CD204 / MSR1 / SCARA1 Molecule
MSR1 / CD204 Molecule Synonym Name
MSR1 / CD204 Protein Products
|Cat No||Species||Product Description|
|MS1-H5226||Human||Human MSR1 / CD204 Protein|
MSR1 / CD204 Molecule Background
Macrophage scavenger receptor 1 (MSR1) is also known as CD204, SCARA1, SR-A, and is class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. Defects in MSR1 may be a cause of prostate cancer (PC) or Barrett esophagus (BE).
- (1) Gough P.J., et al., 1998, J. Lipid Res. 39:531-543.
- (2) Xu J., et al., 2002, Nat. Genet. 32:321-325.
- (3) Orloff M., et al., 2011, JAMA 306:410-419.