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Browse By Molecule Name --->CD121b / IL1RB Molecule

CD121b / IL1RB Molecule  


IL-1 RII / CD121b Molecule Synonym Name

CD121b,IL1RB,IL1R2,CDw121b

IL-1 RII / CD121b Protein Products

Cat No Species Product Description
IL2-H4226HumanHuman IL-1 RII / CD121b Protein
IL2-H4256HumanHuman IL-1 RII / CD121b Protein, Fc Tag

IL-1 RII / CD121b Molecule Background

Interleukin-1 receptor type 2 (IL1R2) is also known as CD121 antigen-like family member B (CDw121b), IL-1 type II receptor, Interleukin-1 receptor type II, belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R2 is non-signaling receptor for IL1A, IL1B and IL1RN, reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

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