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Browse By Molecule Name --->PDCD1 / CD279 Molecule

PDCD1 / CD279 Molecule  


PD-1 / PDCD1 Molecule Synonym Name

PDCD1,PD1,CD279,SLEB2

PD-1 / PDCD1 Protein Products

Cat No Species Product Description
PD1-C5223 Cynomolgus Cynomolgus PD-1 / PDCD1 Protein
PD1-C5254 Cynomolgus Cynomolgus PD-1 / PDCD1 Protein, Fc Tag
PD1-H5221 Human Human PD-1 / PDCD1 Protein (HPLC-verified)
PD1-H5257 Human Human PD-1 / PDCD1 Protein, Fc Tag (HPLC-verified), low endotoxin
PD1-H5284 Human Human PD-1 / PDCD1 Protein, Strep Tag
PD1-H82E4 Human Biotinylated Human PD-1 / PDCD1 (recommended for biopanning), Avi Tag (Avitag™)
PD1-H82F2 Human Biotinylated Human PD-1 / PDCD1, His Tag & Fc Tag, Avi Tag (Avitag™)
PD1-HC214 Human Human PD-1 / PDCD1 Protein, Tag Free, Full Length
PD1-HF257 Human FITC-Labeled Human PD-1 / PDCD1 Protein, Fc Tag
PD1-M5228 Mouse Mouse PD-1 / PDCD1 Protein
PD1-M5259 Mouse Mouse PD-1 / PDCD1 Protein, Fc Tag
PD1-M52A4 Mouse Mouse PD-1 / PDCD1 Protein, mouse IgG2a Fc Tag, low endotoxin
PD1-M82F4 Mouse Biotinylated Mouse PD-1 / PDCD1, Fc Tag, Avi Tag (Avitag™)
PD1-R5253 Rat Rat PD-1 / PDCD1 Protein, Fc Tag
PD1-R52H0 Rabbit Rabbit PD-1 / PDCD1 Protein
PD1-R52H2 Rat Rat PD-1 / PDCD1 Protein
PD1-RB5251 Rabbit Rabbit PD-1 / PDCD1 Protein
PD1-H82F1 Human Biotinylated Human PD-1 / PDCD1, Fc Tag, Avi Tag (Avitag™)

PD-1 / PDCD1 Antibody Products

Cat No Species Product Description
PD1-BNA001 Human Biotinylated Anti-PD-1 Neutralizing Antibody
PD1-NA001 Human Anti-PD-1 Neutralizing Antibody

PD-1 / PDCD1 Molecule Background

Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.

Reference

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