FCGR2B / CD32b Molecule
CD32b / FCGR2B Molecule Synonym Name
CD32b / FCGR2B Protein Products
|Cat No||Species||Product Description|
|CDB-H5228||Human||Human Fc gamma RIIB / CD32b Protein|
|CDB-H82E0||Human||Biotinylated Human Fc gamma RIIB / CD32b, Avi Tag (Avitag?)|
|CDB-M52H7||Mouse||Mouse Fc gamma RIIB / CD32b Protein|
CD32b / FCGR2B Molecule Background
Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.
- (1) Hamada F., et al., 1993, Proc. Natl. Acad. Sci. U.S.A. 90:6305-6309.
- (2) Sarmay G., et al., 1997, Immunol. Lett. 57:159-164.
- (3) Laine D., et al., 2005, J. Gen. Virol. 86:1771-1784.