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Browse By Molecule Name --->FCGR2B / CD32b Molecule

FCGR2B / CD32b Molecule  


CD32b / FCGR2B Molecule Synonym Name

FCGR2B,CD32b,CD32,FCG2,IGFR2,CDw32

CD32b / FCGR2B Protein Products

Cat No Species Product Description
CDB-H5228 Human Human Fc gamma RIIB / CD32b Protein

CD32b / FCGR2B Molecule Background

Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.

Reference

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