CD200 / OX-2 Molecule
CD200 / OX-2 Molecule Synonym Name
CD200 / OX-2 Protein Products
|Cat No||Species||Product Description|
|OX2-H5228||Human||Human CD200 / OX-2 Protein|
|OX2-H5251||Human||Human CD200 / OX-2 Protein, Fc Tag|
CD200 / OX-2 Molecule Background
CD200 is also known as OX-2 membrane glycoprotein (OX-2), is a type-1 membrane glycoprotein, which contains two immunoglobulin domains (1 Ig-like C2-type (immunoglobulin-like) domain and Ig-like V-type (immunoglobulin-like) domain), and thus belongs to the immunoglobulin superfamily. CD200 / OX-2 is widely expressed in multiple cell types. CD200 interacts with a structurally related receptor (CD200R) expressed mainly on myeloid cells and is involved in regulation of macrophage and mast cell function. OX-2 / CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.
- (1) McCaughan, G.W. et al., 1987, Immunogenetics 25:329-335.
- (2) Chen, Z. et al., 2006, Mol Immunol. 43 (6): 579-587.
- (3) Wright GJ., et al., 2003, J. Immunol. 171 (6): 3034–46.