CDH1 / CD324 Molecule
E-Cadherin Molecule Synonym Name
E-Cadherin Protein Products
|Cat No||Species||Product Description|
|ECD-H5222||Human||Human E-Cadherin / Cadherin-1 Protein|
|ECD-H5250||Human||Human E-Cadherin / Cadherin-1 Protein, Fc Tag|
E-Cadherin Molecule Background
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-1 (CDH1) is also known as epithelial cadherin (E-cadherin), CD_antigen (CD324), Uvomorulin (UVO) ECAD and CDHE, CDH1 / CD324 contains 5 cadherin domains. CDH1 / CD324 / ECAD is expressed in non-neural epithelial tissues. CDH1 / E-CAD is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad promotes non-amyloidogenic degradation of Abeta precursors and has a strong inhibitory effect on APP C99 and C83 production. Defects in CDH1 / CD324 / ECAD are the cause of hereditary diffuse gastric cancer (HDGC).
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- (3) Yoon K.-A., et al., 1999, J. Hum. Genet. 44:177-180.