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ROBO4 / ECSM4 Molecule  


ROBO4 Molecule Synonym Name

ROBO4,ECSM4,MRB

ROBO4 Protein Products

Cat No Species Product Description
RO4-H5224HumanHuman ROBO4 Protein

ROBO4 Molecule Background

Roundabout homolog 4 (ROBO4) is also known as Magic roundabout (MRB) and ECSM4, which belongs to the immunoglobulin superfamily or ROBO family. ROBO4 contains 2 fibronectin type-III domains and 2 Ig-like C2-type (immunoglobulin-like) domains. ROBO4 is specifically expressed in endothelial cells and is also expressed at sites of angiogenesis in different tumor types. ROBO4 / MRB is the receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. ROBO-4 may mediate the inhibition of primary endothelial cell migration by Slit proteins.

Reference