EPHA7 / EHK3 Molecule
EphA7 Molecule Synonym Name
EphA7 Protein Products
|Cat No||Species||Product Description|
|EP7-H5221||Human||Human EphA7 Protein|
EphA7 Molecule Background
Ephrin type-A receptor 7 (EPHA7) is also known as EPH homology kinase 3 (EHK3), EPH-like kinase 11 (HEK11), which belongs to the protein kinase superfamily or tyr protein kinase family or ephrin receptor subfamily. EPHA7 / EHK3 contains 1 Eph LBD (Eph ligand-binding) domain, 2 fibronectin type-III domains, 1 protein kinase domain, 1 SAM (sterile alpha motif) domain. EHK-3 / EPHA7 is widely expressed. The catalytic activity of EPHA7 / EHK3 is “ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate”. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
- (1) Nakanishi H., et al., 2007, Proc. Natl. Acad. Sci. U.S.A. 104:14442-14447.
- (2) Tsuboi M., et al., 2010, Int. J. Oncol. 36:635-640.
- (3) Eph nomenclature committee, 1997, Cell 90:403-404.