CD2 / SRBC Molecule
CD2 / SRBC Molecule Synonym Name
CD2 / SRBC Protein Products
|Cat No||Species||Product Description|
|CD2-H5226||Human||Human CD2 / SRBC Protein|
CD2 / SRBC Molecule Background
T-cell surface antigen CD2 is also known as Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor, T-cell surface antigen T11/Leu-5 and SRBC, is a single-pass type I membrane protein found on the surface of T cells and natural killer (NK) cells. CD2 is a member of the immunoglobulin superfamily. CD2 / SRBC contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD2 / SRBC interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3 / CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells. In addition to its adhesive properties, CD2 also acts as a co-stimulatory molecule on T and NK cells. CD2 is a specific marker for T cells and NK cells, and can therefore be used in immunohistochemistry to identify the presence of such cells in tissue sections.
- (1) Wilkins A., et al., 2003, Curr Protein Pept Sci 4 (5): 367–73.
- (2) Yang J., et al., 2001, Curr Protein Pept Sci 2 (1): 1–17.
- (3) Bodian D.L., et al., 1994, Structure 2:755-766.