IL2RG / CD132 Molecule
IL-2 R gamma / CD132 Molecule Synonym Name
IL-2 R gamma / CD132 Protein Products
|Cat No||Species||Product Description|
|ILG-H5256||Human||Human IL-2 R gamma / CD132 Protein, Fc Tag|
IL-2 R gamma / CD132 Molecule Background
IL-2R is a heterotrimeric protein binds and responds to the cytokine IL-2. Three distinct chains of IL-2R, termed as α, β and γ, which are non-covalently associated are identified. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ chain, along with the β subunit. The α chain of the IL-2R can bind to the β chain before receptor interaction with IL-2. The γ chain alone has a very weak affinity for IL-2, but after the ligand is bound to the α/β heterodimer, the γ chain becomes recruited to the complex to form a very stable macromolecular quaternary ligand/receptor complex. Interleukin-2 receptor subunit gamma (IL2RG), also known as cytokine receptor common subunit gamma, CD antigen CD132, gammaC, p64, which belongs to the type I cytokine receptor family or type 5 subfamily. IL2RG is located on the surface of immature blood-forming cells in bone marrow. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID).
- (1) Kondo M., et al., 1993, Science 262:1874-1877.
- (2) Russell S.M., et al., 1993, Science 262:1880-1883.
- (3) Noguchi M., et al., 1993, Science 262:1877-1880.