CD38 / T10 Molecule
CD38 Molecule Synonym Name
CD38,T10,cADPr hydrolase 1
CD38 Protein Products
|Cat No||Species||Product Description|
|CD8-H5224||Human||Human CD38 Protein|
|CD8-H82E7||Human||Biotinylated Human CD38 Protein, Avi Tag (Avitag™)|
CD38 Molecule Background
CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.
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