GHR / GHBR Molecule
GHR Molecule Synonym Name
GHR Protein Products
|Cat No||Species||Product Description|
|GHR-H5222||Human||Human Growth Hormone R (GHR) Protein|
|GHR-H5257||Human||Human Growth Hormone R (GHR) Protein, Fc Tag|
|GHR-H8222||Human||Biotinylated Human Growth Hormone R, ultra sensitivity (primary amine labeling)|
GHR Molecule Background
Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
- (1) Duquesnoy P., et al., 1994, EMBO J. 13:1386-1395.
- (2) Urbanek M., et al., 1993, J. Biol. Chem. 268:19025-19032.