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Browse By Molecule Name --->LILRB4 / ILT3 Molecule

LILRB4 / ILT3 Molecule  


LILRB4 / ILT3 Molecule Synonym Name

LILRB4,ILT3,LIR5,CD85K,HM18

LILRB4 / ILT3 Protein Products

Cat No Species Product Description
LI4-H5259 Human Human LILRB4 /CD85K Protein, With C-Fc Tag
CDK-M5250 Mouse Mouse LILRB4 / CD85k / ILT3 Protein, Fc Tag
CDK-C5258 Cynomolgus Cynomolgus LILRB4 / CD85k / ILT3 Protein, Fc Tag
CDK-M5227 Cynomolgus Cynomolgus LILRB4 Protein, His Tag
CDK-M5229 Mouse Mouse LILRB4 Protein, His Tag

LILRB4 / ILT3 Molecule Background

Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

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