CD58 / LFA3 Molecule
CD58 / LFA-3 Molecule Synonym Name
CD58 / LFA-3 Protein Products
|Cat No||Species||Product Description|
|LF3-H5225||Human||Human CD58 / LFA-3 Protein|
|LF3-H5256||Human||Human CD58 / LFA-3 Protein, Fc Tag|
CD58 / LFA-3 Molecule Background
CD antigen CD58 is also known as Lymphocyte function-associated antigen 3 (LFA-3). CD58 is a cell adhesion molecule expressed on Antigen Presenting Cells (APC), particularly macrophages. CD58 /LFA3 is ligand of the T-lymphocyte CD2 glycoprotein, which binds to CD2 (LFA-2)  on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis.
- (1) Barbosa JA., et al., 1986, J. Immunol. 136 (8): 3085–91.
- (2) Wang JH., et al., 1999, Cell 97 (6): 791–803.
- (3) De Jager PL., et al., 2009, Proc Natl Acad Sci U S A. 106 (13): 5264–9.