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Your Position: Home > Bcl-x

Bcl-x

Brief Information

Name:Apoptosis regulator Bcl-X
Target Synonym:Bcl-2-like protein 1,Bcl2-L-1,BCL2L,Apoptosis regulator Bcl-X,BCL2L1,BCL2 Like 1,Protein Phosphatase 1, Regulatory Subunit 52,BCLX,BCL-XL/S,PPP1R52,Bcl-X,bcl-X Protein,Bcl-XL,Bcl-XS
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
BC1-H513a Human Human Bcl-x / BCL2L1 Protein, GST Tag
BC1-H513a-structure
BC1-H513a-sds
BC1-H5120 Human Human Bcl-x / BCL2L1 Protein, His Tag
BC1-H5120-structure
BC1-H5120-sds
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Synonym Name

BCL2L1,Bcl-XL,Bcl2-L-1,BCL-XL/S,BCL2L,BCLX,BCLXL,BCLXS,Bcl-X,bcl-xS

Background

Bcl-2-like protein 1 (BCL2L1), is also known as Apoptosis regulator Bcl-X (Bcl-XL). BCL2L1 / Bcl-XL is a homodimer protein and belongs to the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a potent inhibitor of cell death. BCL2L1 Inhibits activation of caspases. BCL2L1 appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. BCL2L1 / Bcl-XL also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
R-(-)-gossypol acetic acid AT-101; BL-193; TW-37; NSC-726190 Approved University Of Michigan, Jiangsu Yasheng Pharmaceutical Development Co Ltd, National Institutes Of Health Mainland China Contraception; Genital Diseases, Female Shanxi Panlong Pharmaceutical Group Limited By Share Ltd 2002-01-01 Esophageal Neoplasms; Contraception; Genital Diseases, Female; Glioblastoma; Lymphoma, Large B-Cell, Diffuse; Small Cell Lung Carcinoma; Adrenocortical Carcinoma; Prostatic Neoplasms; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Brain Neoplasms; Gliosarcoma; Leukemia, Lymphocytic, Chronic, B-Cell Details
Gossypol acetic acid/Potassium Chloride/Vitamin B1/Vitamin B6 Approved Mainland China Uterine Hemorrhage; Uterine Neoplasms; Endometriosis Xi'An Beifang Medicine Co Ltd 1988-01-01 Endometriosis; Uterine Hemorrhage; Uterine Neoplasms Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
TGRX-814 TGRX-814 Phase 2 Clinical Shenzhen Tajirui Biomedical Co Ltd Hematologic Neoplasms; Leukemia; Lymphoma Details
Mirzotamab clezutoclax ABBV-155 Phase 1 Clinical Abbvie Inc Solid tumours Details
Pelcitoclax BM-1252; APG-1252 Phase 2 Clinical Jiangsu Yasheng Pharmaceutical Development Co Ltd Solid tumours; Ovarian Neoplasms; Small Cell Lung Carcinoma; Neuroendocrine Tumors; Lymphoma, Extranodal NK-T-Cell; Primary Myelofibrosis; Peritoneal Neoplasms; Lymphoma, Non-Hodgkin; Fallopian Tube Neoplasms; Uterine Neoplasms; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Endometrioid Details
UBX-1325 UBX-1325 Phase 2 Clinical Unity Biotechnology Inc, Ascentage Pharma Group International Macular Edema; Diabetic macular oedema; Macular Degeneration Details
ABBV-637 ABBV-637 Phase 1 Clinical Abbvie Inc Solid tumours; Carcinoma, Non-Small-Cell Lung Details
LP-118 LP-118 Phase 1 Clinical Guangzhou Lupeng Pharmaceutical Co Ltd, Newave Pharmaceutical Inc Lymphoma, B-Cell; Solid tumours; Bone Marrow Neoplasms; Neoplasms; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Multiple Myeloma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Richter's Syndrome; Primary Myelofibrosis; Leukemia, Prolymphocytic, T-Cell; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell Details
DT-2216 DT-2216 Phase 1 Clinical University Of Florida, Dialectic Therapeutics Inc Hematologic Neoplasms; Solid tumours Details

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