LRRC4 / NGL-2 Molecule
LRRC4 Molecule Synonym Name
LRRC4 Protein Products
|Cat No||Species||Product Description|
|LR4-H5221||Human||Human LRRC4 Protein|
LRRC4 Molecule Background
LRRC4 (Leu-rich repeat/LRR-containing glycoprotein 4), LRRC4B and LRRC4C are post-synaptic adhesion molecules of the LRR protein family that induce excitatory synapse formation. LRRC4 is also known as Brain tumor-associated protein BAG, Netrin-G2 ligand (NGL-2), Nasopharyngeal carcinoma-associated gene 14 protein (NAG14), which contains 1 Ig-like (immunoglobulin-like) domain and 9 LRR (leucine-rich) repeats, 1 LRRCT domain, 1 LRRNT domain. LRRC4 / NGL-2 specifically expressed in brain. LRRC4 / NGL-2 regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. LRRC4 / NGL-2 organize the lamina/pathway-specific differentiation of dendrites. LRRC4 / NGL-2 plays a important role for auditory synaptic responses and involved in the suppression of glioma.
- (1) Zhang Q., et al., 2005, FEBS Lett. 579:3674-3682.
- (2) Wang JR., et al., 2003, Ai Zheng 22 (9): 897–902.