PROCR / EPCR Molecule
PROCR / EPCR Molecule Synonym Name
PROCR / EPCR Protein Products
|Cat No||Species||Product Description|
|PRR-H5223||Human||Human PROCR / EPCR / CD201 Protein|
|PRR-H5254||Human||Human PROCR / EPCR / CD201 Protein, Fc Tag|
PROCR / EPCR Molecule Background
Endothelial protein C receptor (PROCR) is also known as Activated protein C receptor (APC receptor), Endothelial cell protein C receptor, CD antigen CD201. PROCR / EPCR / CD201 is a N-glycosylated protein, with a soluble form exists. PROCR is probably released by a metalloprotease. PROCR seems to have the same activity as the membrane-bound form. PROCR / EPCR / CD201 is expressed strongly in the endothelial cells of arteries and veins in heart and lung. PROCR binds activated protein C and enhances protein C activation by the thrombin - thrombomodulin complex. PROCR plays a role in the protein C pathway controlling blood coagulation.
- (1) Fukudome K., et al., 1994, J. Biol. Chem. 269:26486-26491.
- (2) Oganesyan V., et al., 2002, J. Biol. Chem. 277:24851-24854.