AZU1 / HBP Molecule
AZU1 / CAP37 Molecule Synonym Name
AZU1 / CAP37 Protein Products
|Cat No||Species||Product Description|
|AZ1-H5225||Human||Human Azurocidin / CAP37 / AZU1 Protein|
AZU1 / CAP37 Molecule Background
Azurocidin (AZU1) is also known as Heparin-binding protein (HBP), Cationic antimicrobial protein CAP37, is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. which belongs to the peptidase S1 family and elastase subfamily. AZU1 / HBP contains 1 peptidase S1 domain. AZU1 binds heparin. The cytotoxic action of AZU1 is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. AZU1 may play a role in mediating recruitment of monocytes in the second wave of inflammation.
- (1) Wasiluk K.R., et al., 1991, Infect. Immun. 59:4193-4200.
- (2) Miyasaki K.T., 1992, Infect. Immun. 60:4973-4975.
- (3) Linder A., 2009, Clin. Infect. Dis. 49 (7): 1044–50.