CD93 / C1QR1 Molecule
C1q R1 / CD93 Molecule Synonym Name
C1q R1 / CD93 Protein Products
|Cat No||Species||Product Description|
|C11-H5228||Human||Human C1q R1 / CD93 Protein|
C1q R1 / CD93 Molecule Background
CD antigen CD93 is also known as Complement component C1q receptor (C1QR1). which belongs to the Group XIV C-Type lectin family, a group containing two other members, endosialin (CD248) and thrombomodulin. CD93 contains one C-type lectin domain and five EGF-like domains. CD93 is highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. CD93 is receptor for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). CD93 may mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens and may play a role in intercellular adhesion.
- (1) Ghebrehiwet B., et al., 1997, J. Immunol. 159:1429-1436.
- (2) Nepomuceno R.R., et al., 1999, J. Immunol. 162:3583-3589.
- (3) Kittlesen D.J., et al., 2000, J. Clin. Invest. 106:1239-1249.