TXNDC12 Molecule Synonym Name
TXNDC12, ER protein 18, ERp18, ER protein 19, ERp19, hTLP19, TLP19
TXNDC12 Protein Products
|Cat No||Species||Product Description|
|TX2-H5224||Human||Human TXNDC12 Protein|
TXNDC12 Molecule Background
Thioredoxin domain-containing protein 12 (TXNDC12) is also known as Thioredoxin-like protein p19 (TLP19), Endoplasmic reticulum resident protein 18 (ERp18), Endoplasmic reticulum resident protein 19 (ERp19). TXNDC12 belongs to the thioredoxin superfamily. Members of this superfamily possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defense against oxidative stress, refolding of disulfide-containing proteins, and regulation of transcription factors. TXNDC12 possesses significant protein thiol-disulfide oxidase activity. The optimum pH of catalytic activity is 6.5.
- (1) Alanen H.I., et al., 2003, J. Biol. Chem. 278:28912-28920.
- (2) Zhang Z., et al., 2004, Protein Sci. 13:2819-2824.