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Serpin F1 Molecule  


Serpin F1 Molecule Synonym Name

SERPINF1,Serpin F1,PEDF,PIG35,EPC-1

Serpin F1 Protein Products

Cat No Species Product Description
SE1-H5221HumanHuman Serpin F1 / PEDF Protein

Serpin F1 Molecule Background

erpin F1 (SERPINF1) is also known as Pigment epithelium-derived factor (PEDF), Cell proliferation-inducing gene 35 protein (PIG35). Serpin F1 belongs to the serpin family. Serpin F1 is expressed in quiescent cells. PEDF has a variety of functions including antiangiogenic, antitumorigenic, and neurotrophic properties. Endothelial cell migration is inhibited by SERPINF1/ PEDF. PEDF / SERPINF1 suppresses retinal neovascularization and endothelial cell proliferation. PEDF is also responsible for apoptosis of endothelial cells either through the p38 MAPK pathway or through the FAS/FASL pathway. PEDF also displays neurotrophic functions.

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