Serpin F1 Molecule
Serpin F1 Molecule Synonym Name
Serpin F1 Protein Products
|Cat No||Species||Product Description|
|SE1-H5221||Human||Human Serpin F1 / PEDF Protein|
Serpin F1 Molecule Background
erpin F1 (SERPINF1) is also known as Pigment epithelium-derived factor (PEDF), Cell proliferation-inducing gene 35 protein (PIG35). Serpin F1 belongs to the serpin family. Serpin F1 is expressed in quiescent cells. PEDF has a variety of functions including antiangiogenic, antitumorigenic, and neurotrophic properties. Endothelial cell migration is inhibited by SERPINF1/ PEDF. PEDF / SERPINF1 suppresses retinal neovascularization and endothelial cell proliferation. PEDF is also responsible for apoptosis of endothelial cells either through the p38 MAPK pathway or through the FAS/FASL pathway. PEDF also displays neurotrophic functions.
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- (3) Chen L., et al., 2006, Biochem. Biophys. Res. Commun. 348 (4): 1288–95.